Most issues can be resolved, or the resistance is so strong, that the individual is simply looking for a way out.
Privacy - learn the rules of the road
Too much Junk E-mail
Tell the sender that you do not want it. - but only ONCE. Some use a negative response as a way to validate their lists.
Change service or e-mail address and move on.
There are new methods being developed to screen your email. Watch, listen and Learn
Laws are being written that can discourage these services.
What on-line services do you subscribe too? Some subscriptions (but not many) pass your email address along.